One thing I never liked about Emacs was its support for multi major modes (language in language, e.g. CSS in HTML). It is buggy and sucks, although nXhtml did a good job to circumvent lots of these issues.
This is where Sublime Text comes into the game. It is a new and very nice editor, which can be customized by Python plugins to a similiar extent as Emacs. It can handle languages in languages very good and it is fast.
But it has no Emacs-like key bindings. But rejoice! There is sublemacspro! A sublime text package bringing several Emacs features to sublime. Yay, even my beloved region!